Potassium-magnesium citrate is an effective prophylaxis against recurrent calcium oxalate nephrolithiasis.
Potassium-magnesium citrate is an effective prophylaxis
against recurrent calcium oxalate nephrolithiasis.
Ettinger B1, Pak CY, Citron JT, Thomas C, Adams-Huet B,
Vangessel A.
Abstract
PURPOSE:
We examined the efficacy of potassium-magnesium citrate in
preventing recurrent calcium oxalate kidney calculi.
MATERIALS AND METHODS:
We conducted a prospective double-blind study of 64 patients
who were randomly assigned to receive placebo or potassium-magnesium citrate
(42 mEq. potassium, 21 mEq. magnesium, and 63 mEq. citrate) daily for up to 3
years. RESULTS. New calculi formed in 63.6% of subjects receiving placebo and
in 12.9% of subjects receiving potassium-magnesium citrate. When compared with
placebo, the relative risk of treatment failure for potassium-magnesium citrate
was 0.16 (95% confidence interval 0.05 to 0.46). Potassium-magnesium citrate
had a statistically significant effect (relative risk 0.10, 95% confidence
interval 0.03 to 0.36) even after adjustment for possible confounders,
including age, pretreatment calculous event rate and urinary biochemical
abnormalities.
CONCLUSIONS:
Potassium-magnesium citrate effectively prevents recurrent
calcium oxalate stones, and this treatment given for up to 3 years reduces risk
of recurrence by 85%.
J Urol. 1997 Dec;158(6):2069-73.
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