Longer-term outcome
in the prevention of psychotic disorders by the Vienna omega-3 study
Nature Communications 6, Article number: 7934
doi:10.1038/ncomms8934
Long-chain omega-3 polyunsaturated fatty acids (PUFAs) are
essential for neural development and function. As key components of brain
tissue, omega-3 PUFAs play critical roles in brain development and function,
and a lack of these fatty acids has been implicated in a number of mental
health conditions over the lifespan, including schizophrenia. We have
previously shown that a 12-week intervention with omega-3 PUFAs reduced the
risk of progression to psychotic disorder in young people with subthreshold
psychotic states for a 12-month period compared with placebo. We have now
completed a longer-term follow-up of this randomized, double-blind,
placebo-controlled trial, at a median of 6.7 years. Here we show that brief
intervention with omega-3 PUFAs reduced both the risk of progression to
psychotic disorder and psychiatric morbidity in general in this study. The
majority of the individuals from the omega-3 group did not show severe
functional impairment and no longer experienced attenuated psychotic symptoms
at follow-up.
Longer-term outcome
in the prevention of psychotic disorders by the Vienna omega-3 study
G. Paul Amminger,Miriam R. Schäfer,Monika
Schlögelhofer,Claudia M. Klier& Patrick D. McGorry
Nature Communications 6, Article number: 7934
doi:10.1038/ncomms8934
Received 26 November 2014 Accepted 29 June 2015
Published 11 August 2015
Long-chain omega-3 polyunsaturated fatty acids (PUFAs) are
essential for neural development and function. As key components of brain
tissue, omega-3 PUFAs play critical roles in brain development and function,
and a lack of these fatty acids has been implicated in a number of mental
health conditions over the lifespan, including schizophrenia. We have
previously shown that a 12-week intervention with omega-3 PUFAs reduced the
risk of progression to psychotic disorder in young people with subthreshold
psychotic states for a 12-month period compared with placebo. We have now
completed a longer-term follow-up of this randomized, double-blind,
placebo-controlled trial, at a median of 6.7 years. Here we show that brief
intervention with omega-3 PUFAs reduced both the risk of progression to
psychotic disorder and psychiatric morbidity in general in this study. The
majority of the individuals from the omega-3 group did not show severe
functional impairment and no longer experienced attenuated psychotic symptoms
at follow-up.
http://www.nature.com/ncomms/2015/150811/ncomms8934/full/ncomms8934.html
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